The P53627-0AE is HPE's 64GB DDR5-5600 server memory module. It supports HPE ProLiant and Synergy Gen11 systems that need registered ECC memory. This module runs at 5600 MT/s under the PC5-44800 standard, in a dual-rank, x4 layout with CL46 timing. HPE also lists this exact memory under the part number P64707-B21.

P53627-0AE Specifications

• Brand: HPE

• Part Number: P53627-0AE

• Capacity: 64GB (1 x 64GB)

• Speed: 5600 MT/s (PC5-44800)

• Type: DDR5 ECC Registered (RDIMM)

• Rank and Width: Dual Rank, x4

• CAS Latency: CL46

• Voltage: 1.1V

• Pin Count: 288

• Condition: New

What ECC Registered and Dual Rank x4 Mean

Registered memory adds a small buffer chip between the module and your server's memory controller. That buffer lowers the electrical load, so a server can run more DIMMs without instability. Dual rank, x4 describes how the chips are grouped inside the module. Two ranks sit on the board, each built from chips that move 4 bits per cycle. This layout is what lets HPE pack 64GB onto a single stick while keeping error correction active on every byte.

Which HPE Servers Support the P53627-0AE

This module fits HPE ProLiant and Synergy Gen11 systems built for DDR5-5600 registered memory. Common examples include the DL360, DL380, ML350, and Synergy 480 Gen11 lines. These platforms pair it with 4th Gen or 5th Gen Intel Xeon Scalable processors. Server memory limits vary by model, so check your exact QuickSpecs sheet before you place an order.

New and Genuine HPE Stock

Every P53627-0AE listed here is new and carries HPE's Smart Memory authentication, not a generic substitute. HPE builds ECC into the chips, so small memory errors get caught and fixed before they touch your data. That matters most on production servers, where databases, virtual machines, and long backup jobs can fail if a single bit flips unnoticed. CPU Republic works with federal, education, and enterprise buyers who need that kind of reliability confirmed before a purchase order goes out.

Common Questions About the P53627-0AE

Is P53627-0AE the same as P64707-B21?

Yes. Both numbers point to the same HPE 64GB DDR5-5600 dual-rank module. HPE tracks P64707-B21 as the standalone option kit. P53627-0AE covers the identical memory under a different sales channel. The specs match either way, whether your quote lists one number or the other.

Can I mix this module with memory already in my server?

Only if the other DIMMs match in capacity, speed, and rank. HPE Gen11 servers run best with identical modules in each populated channel. Mixing speeds or ranks forces the whole bank down to the slowest module's rating. That can quietly cut your server's memory bandwidth.