HPE AMD EPYC Gen 3 Single-Socket SP3 Server Motherboard

The HPE P40841-001 is an enterprise server motherboard designed for single-socket AMD EPYC Gen 3 (Milan) processors, supporting DDR4 ECC RDIMM/LRDIMM memory, SAS/SATA storage, and high-bandwidth PCIe 4.0 expansion in HPE ProLiant server platforms.

Key Features

• Single-socket AMD EPYC Gen 3 (Milan) SP3 support — up to 64 cores
• DDR4 ECC RDIMM and LRDIMM support across multiple memory channels
• PCIe 4.0 expansion for NVMe, GPU, and high-speed adapter cards
• Integrated SAS/SATA storage controller connectivity
• HPE iLO management controller integration for remote server administration

Product Specifications

• Part Number: P40841-001
• Manufacturer: HPE
• CPU Socket: SP3 (AMD EPYC Gen 3 / Milan)
• CPU Support: Single-socket AMD EPYC 7003 series
• Memory Type: DDR4 ECC RDIMM / LRDIMM
• Storage Interface: SAS / SATA
• PCIe Version: PCIe 4.0

Component Specifications

• Memory Slots: Up to 16 x DIMM slots (platform dependent)
• Max Memory Speed: DDR4-3200
• PCIe Slots: Multiple x16/x8/x4 slots (configuration dependent)
• Management: HPE iLO 5 (Integrated Lights-Out)
• Form Factor: Server board (HPE ProLiant compatible)
• Compatible Platform: HPE ProLiant DL345 Gen10 Plus

Use Cases

• HPE ProLiant server motherboard replacement or spare for EPYC Gen 3 systems
• High-core-count single-socket server builds for virtualization and HPC
• Data center deployments requiring AMD EPYC memory bandwidth and PCIe 4.0 I/O
• Enterprise workloads including database, analytics, and cloud-native applications

Compatibility

• Compatible with AMD EPYC 7003 series (Milan) processors
• Supports DDR4-3200 ECC RDIMM and LRDIMM modules
• Designed for HPE ProLiant DL345 Gen10 Plus server platform
• Managed via HPE iLO 5 and HPE OneView for datacenter automation

Frequently Asked Questions

Is P40841-001 compatible with EPYC Gen 4 (Genoa) processors?

No — this board uses the SP3 socket which supports EPYC Gen 1, 2, and 3 (Rome, Milan). EPYC Gen 4 (Genoa) requires the newer SP5 socket platform.

Does this motherboard include iLO licensing?

HPE iLO 5 is embedded on the board. Advanced iLO features require a separate HPE iLO Advanced license.

Can I use standard DDR4 non-ECC memory?

No — HPE server platforms require ECC-registered (RDIMM) or load-reduced (LRDIMM) DDR4 memory. Standard non-ECC UDIMMs are not supported.

The HPE P40841-001 delivers the full breadth of AMD EPYC Gen 3 platform capabilities — high core density, massive memory bandwidth, and PCIe 4.0 throughput — within the proven HPE ProLiant ecosystem for mission-critical enterprise deployments.