HPE ProLiant ML350 Gen10 4U Tower CTO Server — 877626-B21

The HPE 877626-B21 is the Configure-to-Order (CTO) base unit for the HPE ProLiant ML350 Gen10 4U tower server — supporting Intel Xeon Scalable 2nd Gen (Cascade Lake) processors, DDR4 ECC memory, and up to 8 SFF (2.5-inch) drive bays, providing a versatile enterprise tower platform for SMB, remote office, and departmental workloads requiring flexible HPE Gen10 server configuration.

Key Features

• HPE ProLiant ML350 Gen10 CTO base — configure processor, memory, storage, and I/O to order
• Intel Xeon Scalable 2nd Gen (Cascade Lake) processor support — up to 28-core per socket
• DDR4 ECC RDIMM/LRDIMM support — up to 3200MHz with Gen10 Plus processor upgrade
• 4U tower form factor — ideal for SMB, remote office, and non-rack server deployments
• Up to 8 SFF (2.5-inch) hot-swap drive bays for SAS, SATA, and NVMe storage

Product Specifications

• Part Number: 877626-B21
• Manufacturer: HP / HPE
• Product: HPE ProLiant ML350 Gen10 Tower Server (CTO)
• Form Factor: 4U Tower
• Processor Support: Intel Xeon Scalable 2nd Gen (Cascade Lake), up to 2 sockets
• Memory: Up to 24 DIMM slots, DDR4 ECC RDIMM/LRDIMM, up to 3TB
• Drive Bays: Up to 8x 2.5-inch SFF hot-swap (SAS/SATA/NVMe)
• Expansion: Up to 8 PCIe 3.0 slots

Component Specifications

• Chipset: Intel C621 series
• Network: HPE Embedded 1GbE (4-port) via HPE FlexibleLOM slot
• Power: Redundant hot-plug power supply support (up to 2x 800W)
• Management: HPE iLO 5 (Integrated Lights-Out 5) for remote management
• Security: HPE Silicon Root of Trust, Trusted Platform Module (TPM) 2.0
• OS Support: Windows Server, RHEL, SLES, VMware ESXi

Performance Specifications

• Max Cores: Up to 56 cores (2x 28-core Xeon Scalable 2nd Gen)
• Max Memory: Up to 3TB DDR4 ECC (24 DIMM slots)
• Max Storage: Configurable up to 8x SFF drives + optional M.2 boot drives
• PCIe Bandwidth: Up to 8 PCIe 3.0 slots for NIC, HBA, RAID, and GPU expansion

Use Cases

• SMB primary server for file sharing, print, email, and business application hosting
• Remote/branch office server where rack infrastructure is not available
• Departmental workload consolidation using virtualization (VMware, Hyper-V)
• Database, ERP, and line-of-business application hosting in non-rack environments

Compatibility

• HPE-certified memory, storage, and PCIe accessories for ProLiant ML350 Gen10
• HPE Smart Array controllers for RAID configuration of SAS/SATA drives
• HPE Flexible Smart Array or MR controllers for NVMe/SAS mixed configurations
• Verify component compatibility via HPE's ML350 Gen10 QuickSpecs before configuration

Frequently Asked Questions

What is a CTO (Configure-to-Order) server and what does 877626-B21 include?

CTO (Configure-to-Order) means the 877626-B21 is a base chassis/platform without processor, memory, or storage pre-installed. The buyer configures and orders HPE-certified processors, memory, drives, controllers, and power supplies separately to build the complete server. This allows flexible configuration tailored to specific workload requirements, rather than purchasing a pre-configured bundle.

Does the HPE ML350 Gen10 support rack mounting?

Yes — the HPE ProLiant ML350 Gen10 is designed as a 4U tower server but can be converted to rack mount configuration using the HPE Tower-to-Rack Conversion Kit (sold separately). This makes it suitable for environments that begin as tower deployments and later transition to rack consolidation, without replacing the entire server platform.

What is the difference between HPE ProLiant ML350 Gen10 and ML350 Gen10 Plus?

The ML350 Gen10 (877626-B21) supports Intel Xeon Scalable 2nd Gen (Cascade Lake) processors and DDR4-2933. The ML350 Gen10 Plus supports Intel Xeon Scalable 3rd Gen (Ice Lake) processors with DDR4-3200. The Gen10 Plus also includes updated security features (Silicon Root of Trust enhancements) and PCIe 4.0 support on select slots. For new deployments, the Gen10 Plus or Gen11 platforms are preferred.

The HPE 877626-B21 ProLiant ML350 Gen10 CTO tower server provides a flexible 4U enterprise tower platform supporting Intel Xeon Scalable 2nd Gen processors, up to 3TB DDR4 ECC memory, and 8 SFF drive bays — delivering a configurable HPE Gen10 server foundation for SMB, remote office, and departmental workloads requiring enterprise reliability and HPE iLO 5 management in a tower form factor.